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Virucidal Coatings Active Against SARS-CoV-2статья
- Авторы: Barabanova Anna I., Karamov Eduard V., Larichev Viktor F., Kornilaeva Galina V., Fedyakina Irina T., Turgiev Ali S., Naumkin Alexander V., Lokshin Boris V., Shibaev Andrey V., Potemkin Igor I., Philippova Olga E.
- Журнал: Molecules
- Том: 29
- Номер: 20
- Год издания: 2024
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 4961
- DOI: 10.3390/molecules29204961
- Аннотация: Three types of coatings (contact-based, release-based, and combined coatings with bothcontact-based and release-based actions) were prepared and tested for the ability to inactivateSARS-CoV-2. In these coatings, quaternary ammonium surfactants were used as active agents sincequaternary ammonium compounds are some of the most commonly used disinfectants. To providecontact-based action, the glass and silicon surfaces with covalently attached quaternary ammoniumcationic surfactant were prepared using a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammoniumchloride modifier. Surface modification was confirmed by attenuated total reflection infrared spec-troscopy, X-ray photoelectron spectroscopy (XPS), scanning electron microscopy, and contact anglemeasurements. The grafting density of the modifier was estimated by XPS and elemental analysis.To provide release-based action, the widely used quaternary ammonium cationic disinfectant, ben-zalkonium chloride (BAC), and a newly synthesized cationic gemini surfactant, C18-4-C18, werebound non-covalently to the surface either through hydrophobic or electrostatic interactions. Virustitration revealed that the surfaces with combined contact-based and release-based action and thesurfaces with only release-based action completely inactivate SARS-CoV-2. Coatings containing onlycovalently bound disinfectant are much less effective; they only provide up to 1.25 log10 reductionin the virus titer, probably because of the low disinfectant content in the surface monolayer. Nopronounced differences in the activity between the flat and structured surfaces were observed for anyof the coatings under study. Comparative studies of free and electrostatically bound disinfectantsshow that binding to the surface of nanoparticles diminishes the activity. These data indicate thatSARS-CoV-2 is more sensitive to the free disinfectants.
- Добавил в систему: Барабанова Анна Ивановна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | molecules-29-04961-v2.pdf | 6,8 МБ | 21 октября 2024 [barabanova@polly.phys.su.ru] | |
| 2. | экспертное_заключение.jpg | экспертное_заключение.jpg | 293,8 КБ | 21 октября 2024 [barabanova@polly.phys.su.ru] |