Multiwavelength Fluorescence and Diffuse Reflectance Spectroscopy for an In Situ Analysis of Kidney Stones

Tseregorodtseva, P.S.; Budylin, G.S.; Zlobina, N.V.; Gevorkyan, Z.A.; Filatova, D.A.; Tsigura, D.A.; Armaganov, A.G.; Strigunov, A.A.; Nesterova, O.Y.; Kamalov, D.M.; Afanasyevskaya, E.V.; Mershina, E.A.; Sorokin, N.I.; Sinitsyn, V.E.; Kamalov, A.A.; Shirshin, E.A.

Авторы: Tseregorodtseva Polina S., Budylin Gleb S., Zlobina Nadezhda V., Gevorkyan Zare A., Filatova Daria A., Tsigura Daria A., Armaganov Artashes G., Strigunov Andrey A., Nesterova Olga Y., Kamalov David M., Afanasyevskaya Elizaveta V., Mershina Elena A., Sorokin Nikolay I., Sinitsyn Valentin E., Kamalov Armais A., Shirshin Evgeny A.
Журнал: Photonics
Том: 10
Номер: 12
Год издания: 2023
Номер статьи: 1353
DOI: 10.3390/photonics10121353
Аннотация: This study explores the use of diffuse reflectance spectroscopy (DRS) and multiwavelengthfluorescence spectroscopy for real-time kidney stone identification during laser lithotripsy. Traditionalmethods are not suitable for in situ analysis, so the research focuses on optical techniquesthat can be integrated with lithotripsy fibers. Experiments were conducted ex vivo, using DRSand multiwavelength fluorescence spectroscopy (emission–excitation matrix (EEM)) to distinguishbetween 48 urinary stones of three types: urate, oxalate and hydroxyapatite, with infrared spectroscopyas a reference. A classification model was developed based on EEM and DRS data. Initialclassification relying solely on EEM data achieved an f1-score of 87%, which increased to 92% whenDRS data were included. The findings suggest that optical spectroscopy can effectively determinestone composition during laser lithotripsy, potentially enhancing surgical outcomes via the real-timeautomatic optimization of laser radiation parameters.
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Multiwavelength Fluorescence and Diffuse Reflectance Spectroscopy for an In Situ Analysis of Kidney Stonesстатья Электронная публикация

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