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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Zn-Doped Calcium Magnesium Phosphate Bone Cement Based on Struvite and Its Antibacterial Propertiesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Krokhicheva Polina A., Goldberg Margarita A., Fomin Alexander S., Khayrutdinova Dinara R., Antonova Olga S., Baikin Alexander S., Leonov Aleksander V., Merzlyak Ekaterina M., Mikheev Ivan V., Kirsanova Valentina A., Sviridova Irina K., Akhmedova Suraya A., Sergeeva Natalia S., Barinov Sergey M., Komlev Vladimir S.
- Журнал: Materials
- Том: 16
- Номер: 13
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- DOI: 10.3390/ma16134824
- Аннотация: The development of magnesium calcium phosphate bone cements (MCPCs) has garnered substantial attention. MCPCs are bioactive and biodegradable and have appropriate mechanical and antimicrobial properties for use in reconstructive surgery. In this study, the cement powders based on a (Ca + Mg)/P = 2 system doped with Zn2+ at 0.5 and 1.0 wt.% were obtained and investigated. After mixing with a cement liquid, the structural and phase composition, morphology, chemical structure, setting time, compressive strength, degradation behavior, solubility, antibacterial activities, and in vitro behavior of the cement materials were examined. A high compressive strength of 48 ± 5 MPa (mean ± SD) was achieved for the cement made from Zn2+ 1.0 wt.%-substituted powders. Zn2+ introduction led to antibacterial activity against Staphylococcus aureus and Escherichia coli strains, with an inhibition zone diameter of up to 8 mm. Biological assays confirmed that the developed cement is cytocompatible and promising as a potential bone substitute in reconstructive surgery.
- Добавил в систему: Михеев Иван Владимирович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | materials-16-04824.pdf | 5,1 МБ | 4 июля 2023 [mikheev.ivan] |