Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug

Krasnovskaya, O.O.; Akasov, R.A.; Spector, D.V.; Pavlov, K.G.; Bubley, A.A.; Kuzmin, V.A.; Kostyukov, A.A.; Khaydukov, E.V.; Lopatukhina, E.V.; Semkina, A.S.; Vlasova, K.Y.; Sypalov, S.A.; Erofeev, A.S.; Gorelkin, P.V.; Vaneev, A.N.; Nikitina, V.N.; Skvortsov, D.A.; Ipatova, D.A.; Mazur, D.M.; Zyk, N.V.; Sakharov, D.A.; Majouga, A.G.; Beloglazkina, E.K.

Авторы: Krasnovskaya Olga O., Akasov Roman A., Spector Daniil V., Pavlov Kirill G., Bubley Anna A., Kuzmin Vladimir A., Kostyukov Alexey A., Khaydukov Evgeny V., Lopatukhina Elena V., Semkina Alevtina S., Vlasova Kseniya Yu, Sypalov Sergey A., Erofeev Alexander S., Gorelkin Petr V., Vaneev Alexander N., Nikitina Vita N., Skvortsov Dmitrii A., Ipatova Daria A., Mazur Dmitrii M., Zyk Nikolay V., Sakharov Dmitry A., Majouga Alexander G., Beloglazkina Elena K.
Журнал: ACS applied materials & interfaces
Год издания: 2023
Издательство: American Chemical Society
Местоположение издательства: United States
DOI: 10.1021/acsami.3c01771
Аннотация: Controlled photoreduction of Pt(IV) prodrugs is a challenging task due to the possibility of targeted light-controlled activation of anticancer agents without affecting healthy tissues. Also, a conjugation of photosensitizers and clinically used platinum drugs into one Pt(IV) prodrug allows combining photodynamic therapy and chemotherapy approaches into one molecule. Herein, we designed the cisplatin-based Pt(IV) prodrug Riboplatin with tetraacetylriboflavin in the axial position. A novel Pt(IV) prodrug is able to act both as a photodynamic therapy (PDT) agent through the conversion of ground-state 3O2 to excited-state 1O2 and as an agent of photoactivated chemotherapy (PACT) through releasing of cisplatin under gentle blue light irradiation, without the requirement of a reducing agent. The light-induced behavior of Riboplatin was investigated using an electrochemical sensor in MCF-7 tumor spheroids. Photocontrolled cisplatin release and ROS generation were detected electrochemically in real time. This appears to be the first confirmation of simultaneous photoactivated release of anticancer drug cisplatin and ROS from a dual-action Pt(IV) prodrug observed from the inside of living tumor spheroids.
Добавил в систему: Красновская Ольга Олеговна

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

Интеллектуальная Система Тематического Исследования НАукометрических данных

Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrugстатья