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Effects of Glucocorticoid Receptor Activation on the Expression of Intercellular Adhesion Regulatory Genes in Breast Cancer Cells In Vitroстатья
- Авторы: Grigoreva Diana, Zhidkova Ekaterina, Zhukova Olga, Lesovaya Ekaterina, Yakubovskaya Marianna
- Сборник: Biology and Life Sciences Forum 2022
- Серия: 20
- Том: 11
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- DOI: 10.3390/iecbm2022-13379
- Аннотация: Combinations of anticancer chemotherapeutics with glucocorticoids (GCs) are usually used to broaden the therapeutic range of main cytostatic agents and to diminish the side effects of chemotherapy. However, long-term GC administration leads to tumor resistance and the promotion of metastasis. GC effects are mediated by the glucocorticoid receptor, which regulates gene expression via DNA-dependent transactivation associated with GC side effects and therapeutically important transrepression. We aimed to determine the molecular markers associated with the GC-stimulated motility and migration of breast cancer cells. We showed that GCs stimulate the invasion and metastasis of breast cancer cells after 120 h of treatment and determined markers of GC-associated adhesion loss. Supplementary Materials The following are available online at https://www.mdpi.com/article/10.3390/IECBM2022-13379/s1. Funding Work was partially supported by RSCF (17-75-20124) and RFBR (16-04-01410, 15-04-04006).
- Добавил в систему: Жидкова Екатерина Михайловна