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Transcriptome profile of yeast reveals essential role of PMA2 and uncharacterized gene YBR056W-A (MNC1) in adaptation to toxic manganese concentrationстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Andreeva Nadezhda, Kulakovskaya Ekaterina, Zvonarev Anton, Penin Aleksey, Eliseeva Irina, Teterina Anastasia, Lando Andrey, Kulakovskiy Ivan, Kulakovskaya Tatiana
- Журнал: Metallomics : integrated biometal science
- Год издания: 2017
- Издательство: RSC Publishing
- Местоположение издательства: Cambridge, England
- DOI: 10.1039/C6MT00210B
- Аннотация: Adaptation of S. cerevisiae to toxic concentrations of manganese provides a physiological model of heavy metal homeostasis. Transcriptome analysis of adapted yeast cells reveals upregulation of cell wall and plasma membrane proteins including membrane transporters. The gene expression in adapted cells differs from that of cells under short-term toxic metal stress. Among the most significantly upregulated genes are PMA2, encoding an ortholog of Pma1 H+-ATPase of the plasma membrane, and YBR056W-A, encoding a putative membrane protein Mnc1 that belongs to the CYSTM family and presumably chelates manganese at the cell surface. We demonstrate that these genes are essential for the adaptation to toxic manganese concentration and propose an extended scheme of manganese detoxification in yeast.
- Добавил в систему: Пенин Алексей Александрович