Time-resolved fluorescence imaging technique for rat brain tumors analysisстатья
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Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
Аннотация:The paper presents a new approach to assessing the state of tissues that differ inphenotype and in the degree of immunocompetent cells activity using photosensitizers (PS) andtime-resolved fluorescence analysis methods. The main attention is paid to the detection ofdifferences between tumor cells and tumor-associated macrophages (TAM) using spectroscopicand microscopic methods by the fluorescent kinetics signal and the difference in theaccumulation of PS (the accumulation is several times greater in macrophages). The results ofthe PS photoluminescence study were obtained using two different techniques: time-resolvedspectroscopy and time-resolved fluorescence microscopy (FLIM). Time-resolved spectroscopicanalysis of the PS fluorescence lifetime was performed on adult female rats with induced C6glioma in vivo. 5-ALA-induced Pp IX, which is widely used in clinical practice for carrying outeffective conduction photodiagnostics and PDT, was used as the PS.