Fabrication of calcium phosphate 3D scaffolds for bone repair using magnetic levitational assembly

Parfenov, V.A.; Mironov, V.A.; Koudan, E.V.; Nezhurina, E.K.; Karalkin, P.A.; Pereira, F.D.; Petrov, S.V.; Krokhmal, A.A.; Aydemir, T.; Vakhrushev, I.V.; Zobkov, Y.V.; Smirnov, I.V.; Fedotov, A.Y.; Demirci, U.; Khesuani, Y.D.; Komlev, V.S.

Авторы: Parfenov Vladislav A., Mironov Vladimir A., Koudan Elizaveta V., Nezhurina Elizaveta K., Karalkin Pavel A., Pereira Frederico DAS, Petrov Stanislav V., Krokhmal Alisa A., Aydemir Timur, Vakhrushev Igor V., Zobkov Yury V., Smirnov Igor V., Fedotov Alexander Yu, Demirci Utkan, Khesuani Yusef D., Komlev Vladimir S.
Журнал: Scientific reports
Том: 10
Номер: 1
Год издания: 2020
Издательство: Nature Publishing Group
Местоположение издательства: United Kingdom
DOI: 10.1038/s41598-020-61066-3
Аннотация: The calcium phosphate particles can be used as building blocks for fabrication of 3D scaffolds intended for bone tissue engineering. This work presents for the first time a rapid creation of 3D scaffolds using magnetic levitation of calcium phosphate particles. Namely, tricalcium phosphate particles of equal size and certain porosity are used, which undergo the process of recrystallization after magnetic levitational assembly of the scaffold to ensure stitching of the scaffold. Label-free levitational assembly is achieved by using a custom-designed magnetic system in the presence of gadolinium salts, which allows the levitation of calcium phosphate particles. Chemical transformation of tricalcium- to octacalcium phosphate under the condition of magnetic levitation in non-homogeneous magnetic field is also demonstrated. This approach allows obtaining rapidly the octacalcium phosphate phase in the final 3D product, which is biocompatible.
Добавил в систему: Крохмаль Алиса Александровна

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