Аннотация:Objective. – There is evidence that brain-derived neurotrophic factor (BDNF) has a role in migraine pathophysiology. In our research, association of substitutions in BDNF gene (rs6265, rs11030107, rs2049046) with clinical parameters of migraine is considered.
Background. – Brain-derived neurotrophic factor (BDNF) is a neurotrophin presented widely in central nervous system. BDNF regulates axonal growth and differentiation; synapse formation; activity of dopaminergic, serotoninergic, GABA-ergic, and cholinergic neurons. Apparently, BDNF participates in the development of primary forms of headaches.
Patients and Methods. – The research included 155 patients with migraine (according to ICHD-III, 2013). Control group consisted in 203 unexamined individuals. Patients underwent clinical neurological examination and blood sampling. Genotypes were determined using PCR-RFLP method.
Results. – We did not find significant association between studied SNPs and migraine. We showed that the TT-genotype of rs2049046 influences the migraine chronification the episodes transform by regression of prodromal period, and the endurance of episodes themselves shortens. The GG genotype of rs6265 has no significant influence on formation and manifestation of migraine. Possession of G-allele of rs1030107 influences the formation of drug abuse and higher frequency of photo- and phonophobia during migraine episode.
Conclusions. – Our results suggest that the substitutions rs2049046 and rs1030107 in BDNF gene play role in formation of clinical manifestations of migraine.
