Selective Inhibition of Enterovirus A Species Members’ Reproduction by Furano[2,3-d]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Virusesстатья

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Дата последнего поиска статьи во внешних источниках: 2 мая 2018 г.

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[1] Selective inhibition of enterovirus a species members’ reproduction by furano[2,3-d]pyrimidine nucleosides revealed by antiviral activity profiling against (+)ssrna viruses / L. I. Kozlovskaya, A. D. Golinets, A. A. Eletskaya et al. // ChemistrySelect. — 2018. — Vol. 3, no. 8. — P. 2321–2325. The rational design of broad-spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N4-hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick-borne encephalitis virus. Furano[2, 3-d]pyrimidine nucleosides with n-pentyl or n-hexyl tails showed selective inhibition of Enterovirus A representatives. 5-(Tetradec-1-yn-1-yl)-uridine showed selective inhibition of tick-borne encephalitis virus at the micromolar level. [ DOI ]

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