ИСТИНА

Platelets are critical elements of the hemostasis system that prevent blood loss when the vascular wall is damaged. Nitric oxide (NO), secreted by endothelial cells, serves as a necessary physiological and regulatory biological mediator that modulates vascular wall tone and hemostatic-thrombotic balance [1]. Violation of the NO concentration in the human body leads to various kinds of cardiovascular diseases, including thrombosis, atherosclerosis, etc. It is known that nitric oxide inhibits the adhesion of platelets and leukocytes to the endothelium cell layer, inhibits the activation of platelets and leukocytes [2]. The aim of the work is to quantify the effect of sodium nitroprusside, which is a direct NO donor, on the aggregation properties of platelets by the turbidimetric method in vitro.