Аннотация:The account is focused on the synthesis of 1,4,6,10-tetraazaadamantanes, a new class of heterocage scaffolds isomeric to urotropine (methenamine). The suggested strategy to the assembly of 1,4,6,10-tetraazaadamantane cage employs an intramolecular [2+2+2] cyclotrimerization reaction in a suitable tris-oxime or tris-hydrazone precursor. Various 1,4,6,10-tetraazaadamantane derivatives including unsymmetrically substituted ones are accessible by this route.