Аннотация:In the present Research Topic we collected papers devoted to the different aspects of the noninvasivephotonic techniques capablemonitoring real-timemicrovascular hemodynamics in healthand pathology. Compact laser instruments for near-infrared spectroscopy (NIRS), Laser DopplerFlowmetry (LDF), diffuse correlation spectroscopy (DCS), NIRS flow oximetry, and others areroutinely and widely used for concurrent non-invasive measurement of different parameters ofhemocirculation such as blood perfusion, mean arterial pressure, oxy- and deoxyhemoglobinconcentrations, and others. Further development and introduction of these approaches and systemsto clinical practice will lead to enrichment and step-by-step substitution of laboratory tests withenabling bed-side diagnostics and wireless distantly controlled patient condition monitoring.