Аннотация:The manual provides information on immunobiology of the human immunodeficiency virus type 1 (HIV-1) and its evasion mechanisms. It also covers the development of immune responses in human patients, including antibodies with a broad-range neutralizing activity. These data substantiate a new approach to design effective immunogens and possible vaccine strategies.The manual is intended for students, graduate students, and researchers of the Biology school of Lomonosov Moscow State University and other medical schools. The manual is prepared in support of a special course Immunobiology of HIV and problems of development of HIV-1 vaccine for 2d year Master students at the Department of Immunology, Faculty of Biology, Lomonosov Moscow State University.