Platelet cytochrome c-oxidase activity in patients with acute schizophrenia in the course of their treatment with risperidone

Burbaeva, G.S.; Boksha, I.S.; Turishcheva, M.S.; Savushkina, O.K.; Beniashvili, A.G.; Rupchev, G.E.; Morozova, M.A.

Авторы: Burbaeva Gulnur Sh, Boksha Irina S., Turishcheva Marina S., Savushkina Olga K., Beniashvili Alan G., Rupchev Georgiy E., Morozova Margarita A.
Журнал: Health (Irvine Calif)
Том: 3
Номер: 1
Год издания: 2011
Издательство: Scientific Research Publishing
Местоположение издательства: United States
Первая страница: 13
Последняя страница: 19
DOI: 10.4236/health.2011.31003
Аннотация: Objectives: Testing a hypothesis, that platelet cytochrome c-oxidase (COX) activities in pa-tients with paranoid schizophrenia, acute epi-sode, may be linked to dynamics of their clinical patterns and quality of cognitive functioning under antipsychotic treatment. Methods: Psy-chopathological (PANSS, NSA-16) and cognitive assessments; platelet COX enzymatic activity determination, post-hoc nonparametric statis-tical analysis. Results: Psychopathological and cognitive assessments were done and blood was sampled in patients before (at baseline) and after treatment with risperidone. Following regu- larities were found after the treatment of pa-tients: Significant elevation of COX, wherein the higher was COX at baseline, the more prominent was decrease in PANSSneg and NSA rates; sig-nificant negative correlation between COX and executive time in cognitive tests. When the pa-tient group was divided by median of COX at baseline into two subgroups (greater or equal median, and <median), significantly larger amount of patients with PANSSpos decrease by >20% was assigned to the first subgroup; significantly larger amount of patients with PANSSneg by <20% was assigned to the second group. Conclusions: Therapy with risperidone seems to be more ef-fective for patients with higher COX activity at baseline, but this fact requires further study. Keywords: Schizophrenia; Risperidone; Biochemical Markers; Acute Phase Treatment; Atypical Antipsychotics
Добавил в систему: Рупчев Георгий Евгеньевич

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