Platelet cytochrome c-oxidase activity in patients with acute schizophrenia in the course of their treatment with risperidoneстатья

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1. Полный текст Health20110100002_16105067.pdf 124,7 КБ 6 апреля 2015 [George72]

[1] Platelet cytochrome c-oxidase activity in patients with acute schizophrenia in the course of their treatment with risperidone / G. S. Burbaeva, I. S. Boksha, M. S. Turishcheva et al. // Health. — 2011. — Vol. 3, no. 1. — P. 13–19. Objectives: Testing a hypothesis, that platelet cytochrome c-oxidase (COX) activities in pa-tients with paranoid schizophrenia, acute epi-sode, may be linked to dynamics of their clinical patterns and quality of cognitive functioning under antipsychotic treatment. Methods: Psy-chopathological (PANSS, NSA-16) and cognitive assessments; platelet COX enzymatic activity determination, post-hoc nonparametric statis-tical analysis. Results: Psychopathological and cognitive assessments were done and blood was sampled in patients before (at baseline) and after treatment with risperidone. Following regu- larities were found after the treatment of pa-tients: Significant elevation of COX, wherein the higher was COX at baseline, the more prominent was decrease in PANSSneg and NSA rates; sig-nificant negative correlation between COX and executive time in cognitive tests. When the pa-tient group was divided by median of COX at baseline into two subgroups (greater or equal median, and <median), significantly larger amount of patients with PANSSpos decrease by >20% was assigned to the first subgroup; significantly larger amount of patients with PANSSneg by <20% was assigned to the second group. Conclusions: Therapy with risperidone seems to be more ef-fective for patients with higher COX activity at baseline, but this fact requires further study. Keywords: Schizophrenia; Risperidone; Biochemical Markers; Acute Phase Treatment; Atypical Antipsychotics. [ DOI ]

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