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Dextran Nanoparticles Cross-linked in Aqueous and Aqueous/alcoholic Mediaстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 декабря 2017 г.
- Авторы: Iakobson O.D., Dobrodumov A.V., Saprykina N.N., Shevchenko N.N.
- Журнал: Macromolecular Chemistry and Physics
- Том: 218
- Номер: 10
- Год издания: 2017
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 1600523
- DOI: 10.1002/macp.201600523
- Аннотация: The attractiveness of the dextran nanoparticle application in medicine and pharmacology results from biocompatibility, biodegradability, and nontoxicity of the polymer. However, it still remains a challenge to prepare such nanoparticles in an aqueous medium due to dextran hydrophilicity. Here, the technique of dextran nanoparticle synthesis with the average diameter of 140–450 nm in aqueous and aqueous/ethanolic media is described. The chemical structure of cross-linker used for the dextran nanoparticle stabilization is demonstrated to influence the dextran nanoparticle diameter, size distribution, and ζ-potential. As shown the regulation of the nanoparticle diameter and ζ-potential is possible through the surfactants and/or dextran nonsolvent (ethanol) addition into the reaction medium. Due to the additional steric stabilization, the dextran nanoparticles of minimum diameter are formed in the presence of ionic surfactants in the aqueous/ethanolic medium. The nanoparticle shape and diameter are analyzed by dynamic light scattering, transmission electron microscopy, and scanning electron microscopy; the composition is investigated by 1H NMR spectroscopy.
- Добавил в систему: Якобсон Ольга Дмитриевна