Novel physiologically active metal complexes of sulphimideтезисы доклада

Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.

Работа с тезисами доклада


[1] Novel physiologically active metal complexes of sulphimide / D. Shpakovsky, К. А. Rufanov, M. Neganova et al. // 27th International Chugaev Conference on Coordination Chemistry and 4th Young Conference School "Physicochemical Methods in the Chemistry of Coordination Compounds". Book of Abstracts. — Типография ННГУ им. Н.И. Лобачевского Nizhny Novgorod, 2017. — P. P217–P217. Sulfimides demonstrate a wide spectrum of biological activity due to coordination ability of N and S atoms, and lability of S=N bond. Although their use in medicine is limited by relative toxicity. The aim of present study was the synthesis of new sulfimide complexes and investigation of their antioxidant properties. The novel compounds 1-3 based on the S,S-diphenylsulfimide were synthesized and characterized. The number of coordinated sulfimides depends on the nature of metal. The structure of complex 2 was determined by X-ray diffraction analysis. It is known that oxidative stress and excessive level of lipid peroxidation in organism is a main reason of several diseases including neurodeneration. The antioxidant activity of the compounds was evaluated in the processes of Fe3+ induced lipid peroxidation of rat brain homogenates. It was shown that the compounds 1, 3 do not possess antioxidant properties while Co complex demonstrats high antioxidant effect. The IC50 value was found 3.5 μМ for compound 2. Unlike its Zn and Ni analogues, Co(II) complex is the redox-active one, cobalt atom can reversibly be involved in electron transfer. Apparently, the high activity of 2 may be attributed to electron transfer from Co2+ to peroxyl radicals responsible for lipids oxidative destruction.

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