Highly active fractions of the medicinal leech recombinant destabilase-lysozyme

Авторы: Fadeeva IuI, Antipova NV, Baskova IP, Zavalova LL
Журнал: Biomeditsinskaia khimiia
Том: 60
Номер: 3
Год издания: 2014
Издательство: Rossiiskaya Akademiya Meditsinskikh Nauk
Местоположение издательства: Russian Federation
Первая страница: 332
Последняя страница: 337
DOI: 10.18097/pbmc20146003332
Аннотация: From the highly purified but lowly active recombinant protein Destabilas-Lysozyme (Dest-Lys) by use cation-exchange column TSK CM 3-SW chromatography, it was separated non-active fraction IV, contained 90% of protein. Fractions I, II and III, represented proteins with lysozyme and isopeptidase activities. Their lysozyme activity correlates with the activity of natural Des-Lys. The ratio of the activities in fractions I - III is such, that maximal lysozyme activity is concentrated in fraction III, isopeptidase - in fraction I. It is discussed the possibility of Dest-Lys different functions regulation is depended on the formation of protein complex forms.
Добавил в систему: Фадеева Юлия Игоревна

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