Multidrug resistance p-glycoprotein inhibits antiapoptotic action of mitochondria-targeted antioxidant SkQR1статья

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[1] Multidrug resistance p-glycoprotein inhibits antiapoptotic action of mitochondria-targeted antioxidant skqr1 /  Fetisova, K. E,  Avetisyan et al. // Cell and Tissue Biology. — 2011. — Vol. 5, no. 1. — P. 37–46. Mitochondria-targeted antioxidants of the SkQ family that accumulate in energized mitochondria protect cells from oxidative stress by increasing the level of reduced glutathione and decreasing cell damage induced by hydrogen peroxide. The exposure of various human transformed cell lines to SkQR1, a fluorescent member of the SkQ family, showed that SkQR1 was pumped out of the chemotherapy resistant cells by P-glycoprotein, one of the main transport proteins that determines multidrug resistance typical for many neoplastic cells. It was also shown that SkQR1 pumping is neutralized by P-glycoprotein inhibitors (verapamil and pluronic L61). In experiments on K-562 cells, it was found that the subline sensitive to chemotherapy is protected by SkQR1 from apoptosis induced by hydrogen peroxide. The protection of resistant subline cells is only evident after the inhibition of P-glycoprotein. [ DOI ]

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