Combination therapy of tumor model with PDT in radiological regions

Авторы: Miyoshi N., Karaya K., Shimada I., Tanaka H., Sakurai Y., Suzuki M., Zaitsev A.V., Ol‘shevskaya V.A., Rychkov G.N., Ono K., Kalinin V.N., Shtil A.A.
Журнал: Materials, methods & technologies
Том: 11
Год издания: 2017
Первая страница: 395
Последняя страница: 402
Аннотация: Fluorinated boron-10 chlorin derivative {5,10,15,20-tetrakis[4-(1-carba-closo-dodecaboran-1-yl)tetrafluorophenyl]-17,18-dihydroporphyrin)]tetrasodium compound demonstrated a striking potential in sensitizing the experimental tumors notonly to PDT and BNCT but also to ionizing irraditian with carbon or proton particles. “Three enhancersin one molecule” allow for combining several therapeutic modalities, e.g., PDT and gamma rays in acompact laser instrument with a thermal neutron source or synchrotron. The newly discovered effect oftumor sensitization by fluorinated boron-containing chlorin derivative deserves further investigation asa promising background for clinical use of heavy ionizing particle radiation therapy.
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