Аннотация:Natural substances, as safe and pluripotent candidates for designing medicinal
products, draw interest of various scientific communities. By the present time methods for
extraction and characterization of individual polyphenolic compositions and a solid
evidence-based scientific database on potential molecular targets of these compositions
have been developed.
Biological activity of BP-Cx-1 was assessed by Dr. R. N. Karapetian et al. (ChemRar
Institute), using in-vitro Cerep Diversity Profile (P9) screening panel. It was demonstrated
that BP-Cx-1 interacts with 40 of the 97 tested targets. Biological activity of BP-Cx-1 was
also simulated in-silico using the following input parameters: results of HPLC/HPLC-MS,
obtained by the scientific group headed by Dr. E. I. Savelyeva (Scientific-Research
Institute of Human Hygiene, Professional pathologies and Ecology of Federal MedicalBiological Agency of Russia, Saint-Petersburg), results of CHN, 13C NMR and FTICR-MS,
latter ones generated by the group of Prof. I. V. Perminova (Moscow State University n.a.
M.V. Lomonosov, Moscow) and results of 1H NMR, generated by Dr. K. A. Krasnov
(Scientific Research Institute of Toxicology, Saint-Petersburg). CHN analyses
demonstrated that BP-Cx-1 does not comprise any nitrogen-containing components; NMR
spectra indicate that BP-Cx-1 comprises predominantly highly substituted polyphenols.