Аннотация:The microbial resistance to antibiotics is a global threat. Effectiveness of well-known
single-molecule beta-lactamase inhibitors (BLIs) has diminished with the evolution of
bacteria. Hence, new multi-target agents are in high demand. In this respect, humic
substances (HS) deserve particular attention. HS are the products of abiotic combinatorial
synthesis yielding supramolecular mixtures of natural organic compounds formed mostly
by phenolic and carboxylic units. It was reported that they possess a broad spectrum of
biological activity, such as anti-inflammatory and antiviral. Here we present a new BLIs
and HS combination as an agent against TEM-1 beta-Lactamase.