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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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HLA ALLELE REPERTOIRE IN RUSSIAN CLL PATIENTS WITH AN UNFAVORABLE PROGNOSISстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 22 апреля 2026 г.
- Авторы: BIDERMAN B.V.1, LIKOLD E.B.1, ABDRAKHIMOVA A.R.1, LEONOV E.A.1, KHAMAGANOVA E.G.1, SUDARIKOV A.B.
- Журнал: HLA
- Том: 95
- Номер: 4
- Год издания: 2020
- Первая страница: 409
- Последняя страница: 409
- DOI: 10.1111/tan.13844
- Аннотация: Chronic lymphocytic leukemia (CLL) is a common lymphoproliferative disease with diverse prognosis. The mutational status of the immunoglobulin heavy chain variable region genes (IGHV) has long been known as an important factor for long-term prognosis in CLL. About 30% of all CLL cases have immunoglobulin receptors with very similar so called stereotyped receptors (SARs). The majority of SARs are composed from unmutated IGHV genes (mainly of the 1 st family) and associated with especially unfavorable prognosis. The purpose of this study was to study the repertoire of HLA alleles in CLL patients with an unfavorable prognosis. The study included 100 CLL patients with unmutated IGHV genes -50 with SARs and 50 with non-stereotyped antigenic receptors and healthy donors as a control group. The group of B*18 alleles was found much more common in patients with SARs than in donors and in patients without SARs. HLA-B*39 was more frequent for patients with SARs compared to donors; in patients without SARs these alleles were not found...
- Добавил в систему: Бидерман Белла Вениаминовна