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Gradient Hydrogels: Fabrication Strategies and Biomedical Applicationsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 апреля 2026 г.
- Авторы: Yabbarov Nikita G., Romashkin Ivan V., Zakharova Vasilina A., Zinovieva Darya N., Mollaeva Mariia R., Sokol Maria B., Chirkina Margarita V., Gulyaev Ivan A., Klimenko Maksim A., Nikolskaya Elena D.
- Журнал: Biochemistry (Moscow)
- Том: 91
- Номер: S1
- Год издания: 2026
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: S251
- Последняя страница: S281
- DOI: 10.1134/s0006297925604137
- Аннотация: Gradient hydrogels represent a unique class of biomaterials capable of mimicking the spatial heterogeneity of native tissues and providing targeted effects on cells through mechanical, chemical, and biophysical gradients. In recent years, numerous fabrication strategies have been developed to generate gradient hydrogels, including layer-by-layer formation, photopolymerization, microfluidic techniques, and 3D/4D printing. This review summarizes current methodologies for the characterization of gradient hydrogels and highlights their emerging biomedical applications, such as controlled drug delivery, tissue engineering, regenerative medicine, organ-on-chip systems, and soft bioelectronic devices. Furthermore, the review discusses critical challenges related to the protocol standardization, manufacturing scalability, integration with additive manufacturing technologies, and potential regulatory barriers.
- Добавил в систему: Захарова Василина Александровна