Semiflexible amphiphilic polymers: Cylindrical-shaped, collagenlike, and toroidal structuresстатья

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Дата последнего поиска статьи во внешних источниках: 11 сентября 2012 г.

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[1] Semiflexible amphiphilic polymers: Cylindrical-shaped, collagenlike, and toroidal structures / V. V. Vasilevskaya, V. A. Markov, P. G. Khalatur, A. R. Khokhlov // Journal of Chemical Physics. — 2006. — Vol. 124, no. 14. A coarse-grained model is used to study the conformational properties of semiflexible polymers with amphiphilic monomer units containing both hydrophilic and hydrophobic interaction sites. The hydrophobically driven conformational transitions are studied using molecular dynamics simulations for the chains of varying stiffness, as characterized by intrinsic Kuhn segment lengths that vary over a decade. It is shown that the energy of hydrophobic attraction required for the realization of the coil-to-globule transition increases with increasing chain stiffness. For rather stiff backbone, the coil-to-globule transition corresponds to a first order phase transition. We find that depending on the chain stiffness, a variety of thermodynamically stable anisometric chain morphologies are possible in a solvent selectively poor for hydrophobic sites of amphiphilic monomer units. For flexible chains, the amphiphilic polymer forms a cylindrical globule having blob structure with nearly spherical blobs. With increasing stiffness, the number of blobs composing the globule decreases and the shape of blobs transforms into elongated cylinder. Further increase in stiffness leads to compaction of macromolecules into a collagenlike structure when the chain folds itself several times and different strands wind round each other. In this state, the collagenlike structures coexist with toroidal globules, both conformations having approximately equal energies. (c) 2006 American Institute of Physics. [ DOI ]

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