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Dearomative Vinylation of Indoles via Multicomponent Photoredox Thiol‐Yne‐Heteroarene Coupling Reactionстатья
- Авторы: Kobelev Andrey D., Li Muzi, Shlapakov Nikita S., Burykina Julia V., You Shu‐Li, Ananikov Valentine P.
- Журнал: Chemistry - A European Journal
- Том: 32
- Номер: 6
- Год издания: 2025
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Номер статьи: e03346
- DOI: 10.1002/chem.202503346
- Аннотация: Dearomative addition reactions of indoles represent a prominent strategy for the synthesis of practically valuable indolines. However, implementing this approach typically requires prefunctionalization of the indole precursor with specific groups (e.g., alkynes, alkenes, or ketones) to facilitate the subsequent cyclization-dearomatization step. In this work, we report a three-component, thiol-yne-mediated dearomative vinylation of indoles that circumvents the need for preinstalling reactive fragments into the indole scaffold. The developed photoredox-catalyzed thiol-yne-heteroarene reaction employs Boc-protected indole-3-carboxylates as effective terminating agents for the radical cascade.
- Добавил в систему: Анаников Валентин Павлович