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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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DEXTRAN-POLY-ε-CAPROLACTONE MICRO- AND NANOPARTICLES: PREPARATION, CHARACTERIZATION AND TAMOXIFEN SOLUBILIZATIONстатья
- Авторы: VILLEMSON A., LARIONOVA N., COUVREUR P., GREF R., GILLET B.
- Журнал: Journal of Drug Delivery Science and Technology
- Том: 16
- Номер: 4
- Год издания: 2006
- Издательство: Editions de Sante
- Местоположение издательства: France
- Первая страница: 307
- Последняя страница: 313
- Аннотация: This work deals with new poly-ε-caprolactone grafted dextran copolymers (Dex-PCL) able to solubilize tamoxifen, a poorly water soluble drug. Micro- and nanoparticles with sizes ranging from 100 to 3,000 nm, composed of Dex-PCL with various Dex contents, were prepared by the nanoprecipitation technique. Structural and surface characterization by dextranase degradation in comparison with the data obtained from the NMR studies proved core-shell structure of these nanoparticles. The PCL core of the Dex-PCL nanoparticles was degraded by the Pseudomonas lipase. Encapsulation of tamoxifen in biodegradable Dex-PCL nanoparticles resulted in loadings as high as 44 wt %. In vitro release studies of tamoxifen performed in phosphate buffer containing 0.5% (w/v) sodium lauryl sulfate showed a sustained release over more than 72 h. This result confirms that most of drug was located in the core of Dex-PCL nanoparticles.
- Добавил в систему: Виллемсон Александр Леонидович