AMPHIPHILIC POLY-N-VINYLPYRROLIDONE NANOCARRIERS WITH INCORPORATED MODEL PROTEINS

Авторы: KUSKOV A.N.1, SHTILMAN M.I.1, VILLEMSON A.L.2, LARIONOVA N.I.2, TSATSAKIS A.M.3, TSIKALAS I.4., RIZOS A.K.
Журнал: Journal of Physics Condensed Matter
Том: 19
Номер: 20
Год издания: 2007
Издательство: IOP Publishing
Местоположение издательства: [Bristol, UK], England
Первая страница: 205139
Последняя страница: 205140
Аннотация: New nanoscaled polymeric carriers have been prepared on the basis of different amphiphilic water-soluble derivatives of poly-N-vinylpyrrolidone (PVP). The polymer self-assembly and interaction with model proteins (Bowman-Birk soybean proteinase inhibitor (BBI) and its hydrophobized derivatives) were studied in aqueous media. The possibility of inclusion of both BBI and hydrophobized oleic acid derivatives of BBI in amphiphilic PVP aggregates was investigated. It was ascertained that polymeric particles of size 50-80 nm were formed in certain concentrations of amphiphilic PVP and poorly soluble dioleic acid derivatives of BBI. Such polymeric aggregates are capable of solubilization of dioleoyl BBI with a concomitant prevention of its inactivation at low pH values.
Добавил в систему: Виллемсон Александр Леонидович

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