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In vitro photodynamic efficacy of polycationic photosensitizers based on longwave phthalocyaninesстатья
Статья опубликована в журнале из списка Web of Science и/или Scopus
- Авторы: Romanishkin I.D., Meerovich I.G., Bunin D.A., Skobeltsin A.S., Akhlyustina E.V., Levkin V.V., Kharnas S.S., Kogan E.A., Zhi-Long Chen, Meerovich G.A., Gorbunova Yu G., Reshetov I.V.
- Журнал: Biomedical Photonics
- Том: 14
- Номер: 3
- Год издания: 2025
- Издательство: Некоммерческое партнерство развития отечественной фотодинамической терапии и фотодиагностики "Национальная фотодинамическая ассоциация"
- Местоположение издательства: Москва
- Первая страница: 24
- Последняя страница: 29
- DOI: 10.24931/2413-9432-2025-14-3-24-29
- Аннотация: Polycationic photosensitizers have previously demonstrated high in vitro efficacy against lung cancer cells, including cancer stem cells, and low dark cytotoxicity. Polycationic phthalocyanines have high quantum yield of singlet oxygen and photostability. In addition, it is possible to relatively simply introduce different metal-complexing agents and substituents into phthalocyanine macrocycles, which enables varying their photophysical characteristics. In this work, we studied photophysical properties of photosensitizers based on polycationic phthalocyanine derivatives withdifferent chemical structure with strong absorption in the long wavelength region (680–690 nm). The studied photosensitizers exhibit negligible aggregation in the 1–100 μM concentration range and show very high phototoxicity in an in vitro study on A549 lung carcinoma cells (IC50 of 60–100 nM for ZnPcChol8 and 100–300 nM for 4αZnPc4+ and 4αβZnPc4+, depending on the light dose), and low dark cytotoxicity.
- Добавил в систему: Бунин Дмитрий Александрович