Exploring the Evolution of the Cariogenic Oral Pathobiont Streptococcus mutans Using Ancient DNA

Michel, M.; Valtueña, A.A.; Akar, M.; Alonso-Fernández, C.; Calmet, M.A.; Andreadaki-Vlazaki, M.; Jiménez, G.A.; Bánffy, E.; Barquera, R.; Barreto Romero, M.I.; Fuello, P.B.; Bedford, S.; Belinskiy, A.B.; Berezina, N.; Boyadzhiev, K.; Boyadzhiev, Y.; Buzhilova, A.; Cappuccini, L.; Huamaní José, E.C.; Beltrán, E.C.; Clark, G.; Daubaras, M.; Ibáñez, P.d.; Bonilla, M.D.; Dobeš, M.; Dresely, V.; Erdal, Y.S.; Ernée, M.; Ferraz, T.; Figuti, L.; Farré, J.F.; Flexner, J.; Friederich, S.; Gaffney, D.; Atiénzar, G.G.; Pena, R.G.; Gómez-Valdés, J.A.; Gradoli, M.G.; Guàrdia, i.L.; Guevara, E.K.; Hansen, S.; Hernandez-Zaragoza, D.I.; Hiss, A.N.; Ingman, T.; Jankauskas, R.; Echevarría, J.J.; Kantorovich, A.R.; Köhler, K.; Kuautonga, T.; Lalueza-Fox, C.; Llamas, B.; López-Cortés, I.; Lull, V.; Magomedov, R.G.; Majander, K.; Marquez, L.; Rodríguez, A.M.; Maslov, V.E.; Massy, K.; Meller, H.; Pérez, R.M.; García, L.M.; Mittnik, A.; Morris, A.G.; Nägele, K.; Nelson, E.A.; Neumann, G.U.; Caravatti, C.O.; Onkamo, P.; Osztás, A.; Papac, L.; Plens, C.R.; Pompianu, E.; García, J.P.; Posth, C.; Protopapadaki, E.; Reinhold, S.; Herrada, C.R.; Risch, R.; Guerra Manuel, A.R.; Romero, A.; Sajantila, A.; Salazar-García, D.C.; Salie, T.; Romero, M.S.; Sayer, D.; Schiffels, S.; Schunke, T.; Sevkar, A.; Shafiq, R.; Shing, R.; Skeates, R.; Skourtanioti, E.; Sperduti, A.; Spyrou, M.A.; Stockhammer, P.W.; Strauss, A.; Summerhayes, G.; Szécsényi-Nagy, A.; Rodriguez, C.T.; Valentin, F.; Valverde, G.; Vasks, A.; Felipe, C.V.; Suárez, M.V.; Villalba-Mouco, V.; Willie, E.; Yener, K.A.; Zariņa, G.; Zinger, W.; Warinner, C.; Haak, W.; Herbig, A.; Krause, J.

Авторы: Michel Megan, Valtueña Aida Andrades, Akar Murat, Alonso-Fernández Carmen, Calmet Micaela Alvarez, Andreadaki-Vlazaki Maria, Jiménez Gonzalo Aranda, Bánffy Eszter, Barquera Rodrigo, Barreto Romero Maria Inés, Fuello Paula Becerra, Bedford Stuart, Belinskiy Andrey B., Berezina Natalia, Boyadzhiev Kamen, Boyadzhiev Yavor, Buzhilova Alexandra, Cappuccini Luca, Huamaní José Enrique Ccencho, Beltrán Eva Celdrán, Clark Geoffrey, Daubaras Mantas, Ibáñez Patxuka de Miguel, Bonilla Marta Díaz-Zorita, Dobeš Miroslav, Dresely Veit, Erdal Yılmaz Selim, Ernée Michal, Ferraz Tiago, Figuti Levy, Farré Joan Francès, Flexner James, Friederich Susanne, Gaffney Dylan, Atiénzar Gabriel García, Pena Rafael Garrido, Gómez-Valdés Jorge A., Gradoli Maria Giuseppina, Guàrdia i.Llorens Marc, Guevara Evelyn K., Hansen Svend, Hernandez-Zaragoza Diana Iraiz, Hiss Alina N., Ingman Tara, Jankauskas Rimantas, Echevarría Javier Jiménez, Kantorovich Anatoliy R., Köhler Kitti, Kuautonga Takaronga, Lalueza-Fox Carles, Llamas Bastien, López-Cortés Isabel, Lull Vicente, Magomedov Rabadan G., Majander Kerttu, Marquez Lourdes, Rodríguez Andrés Martínez, Maslov Vladimir E., Massy Ken, Meller Harald, Pérez Rafael Micó, García Lara Milesi, Mittnik Alissa, Morris Alan G., Nägele Kathrin, Nelson Elizabeth A., Neumann Gunnar U., Caravatti Camila Oliart, Onkamo Päivi, Osztás Anett, Papac Luka, Plens Cláudia R., Pompianu Elisa, García Juana Ponce, Posth Cosimo, Protopapadaki Eftychia, Reinhold Sabine, Herrada Cristina Rihuete, Risch Roberto, Guerra Manuel A.Rojo, Romero Alejandro, Sajantila Antti, Salazar-García Domingo C., Salie Tasneem, Romero Margarita Sánchez, Sayer Duncan, Schiffels Stephan, Schunke Torsten, Sevkar Arda, Shafiq Rula, Shing Richard, Skeates Robin, Skourtanioti Eirini, Sperduti Alessandra, Spyrou Maria A., Stockhammer Philipp W., Strauss André, Summerhayes Glenn, Szécsényi-Nagy Anna, Rodriguez Cristina Tejedor, Valentin Frédérique, Valverde Guido, Vasks Andrejs, Felipe Carlos Velasco, Suárez Miriam Vílchez, Villalba-Mouco Vanessa, Willie Edson, Yener Kutlu Aslihan, Zariņa Gunita, Zinger Wanda, Warinner Christina, Haak Wolfgang, Herbig Alexander, Krause Johannes
Журнал: bioRxiv (The preprint server for biology)
Год издания: 2025
DOI: 10.64898/2025.12.02.691581
Аннотация: The oral pathobiont Streptococcus mutans can contribute to dental caries development through metabolism of dietary carbohydrates. Adoption of carbohydrate-rich agricultural diets is associated with increased prevalence of dental caries in archaeological populations; however, the evolutionary impact of changing subsistence strategies on cariogenic microbes like S. mutans remains to be explored. Here, we use a novel hybridization capture reagent to generate genome-wide ancient DNA data from a global set of 75 S. mutans strains spanning the last 8,000 years. Most virulence-associated genes predate the origins of agriculture; however, we highlight loci regulating genetic competence, bacteriocin production, and biofilm formation which are absent in 5 strains from pre-agricultural ancient hunter-gatherers, suggesting that their acquisition may have been associated with adaptation to carbohydrate-rich agricultural diets. Together, our study highlights ancient DNA as a promising tool for exploring the dynamic interplay between subsistence strategy, microbes, and dental pathology in human populations through time.
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Exploring the Evolution of the Cariogenic Oral Pathobiont Streptococcus mutans Using Ancient DNAстатья