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Altered thalamotemporal structural connectivity is associated with autistic traits in children with ASDстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 января 2026 г.
- Авторы: Minnigulova Alina, Karpychev Victor, Davydova Elizaveta, Pereverzeva Darya, Sorokin Alexander, Tyushkevich Svetlana, Mamokhina Uliana, Danilina Kamilla, Dragoy Olga, Arutiunian Vardan
- Журнал: Behavioural Brain Research
- Том: 481
- Год издания: 2025
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 1
- Последняя страница: 8
- Номер статьи: 115414
- DOI: 10.1016/j.bbr.2024.115414
- Аннотация: Background Thalamocortical functional and structural connectivity alterations may contribute to clinical phenotype of Autism Spectrum Disorder (ASD). As previous studies focused mainly on thalamofrontal connections in ASD, we comprehensively investigated the thalamic functional networks and white matter pathways projecting also to temporal, parietal, occipital lobes and their associations with core and co-occurring conditions of this population. Methods A total of 38 children (19 with ASD) underwent magnetic resonance imaging and behavioral assessment. Functional and structural scans were processed to analyze between-group thalamic connectivity differences and their relationships to measurements of autistic traits and language abilities. Results No functional differences were found between groups across 20 networks in each hemisphere. However, we showed that the diffusion properties of thalamocortical pathways projecting to the right and left temporal lobes were disrupted in children with ASD. Additionally, there was a significant association between diffusion differences of thalamotemporal tracts and severity of autistic traits. Conclusions Our findings on altered thalamotemporal structural but not functional connectivity contribute to the understanding of white matter organization of thalamocortical pathways in children with ASD.
- Добавил в систему: Драгой Ольга Викторовна
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