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A One-Trial Mouse Model of Highly Stable Trauma-Induced Long-Term Memoryстатья
- Авторы: Zamorina T.A., Toropova K.A., Ivashkina O.I., Anokhin Konstantin Vladimirovich
- Журнал: Doklady Biological Sciences
- Том: 524
- Номер: 1
- Год издания: 2025
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 1
- Последняя страница: 4
- DOI: 10.1134/S0012496625600435
- Аннотация: The formation and lifelong maintenance of memory remain one of the central unsolved problemsof neuroscience. Although many experimental models have been developed to study memory, there is cur-rently no paradigm that would make it possible to reliably investigate the memory mechanisms over times-cales comparable to lifespan. In this study, mice were tested for the ability to form highly stable long-termmemory in a contextual fear conditioning paradigm, an adapted model of posttraumatic stress disorder(PTSD). with varying intensities of. A one-trial learning model was developed by varying the intensity ofaversive stimulation. Model mice reliably formed long-term associative memories that persisted for at least6 months. The model thus provides a promising tool for investigating the molecular and neuronal networkmechanisms of lifelong memory retention.
- Добавил в систему: Заморина Татьяна Александровна