Аннотация:Guanylins are intestinal natriuretic peptides that regulate water and electrolyte balance in the intestineand kidney. Their primary receptor is membrane guanylyl cyclase C (GC-C), while alternative functionsrelated to feeding behavior and olfactory preferences are mediated by guanylyl cyclase D (GC-D) expressedexclusively in olfactory neurons. Evidence suggests existence of unidentified receptors activated by guanylinpeptides in the absence of GC-C that affect sodium metabolism. Some of these receptors trigger the cGMP-dependentsignaling pathways typical exclusively for guanylyl cyclases. This review provides a comparativeanalysis of the existing data on different membrane receptor guanylyl cyclases, including early discoveriesand contemporary research, focusing on their potential as guanylin targets.
