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Blood Lead Levels and Delayed Onset of Puberty in a Longitudinal Study of Russian Boysстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.
- Авторы: Williams Paige L., Sergeyev Oleg, Lee Mary M., Korrick Susan A., Burns Jane S., Humblet Olivier, DelPrato Julie, Revich Boris, Hauser Russ
- Журнал: Pediatrics
- Том: 125
- Номер: 5
- Год издания: 2010
- Издательство: American Academy of Pediatrics
- Местоположение издательства: United States
- Первая страница: E1088
- Последняя страница: E1096
- DOI: 10.1542/peds.2009-2575
- Аннотация: OBJECTIVE: We evaluated the association of blood lead levels (BLLs) with pubertal onset in a longitudinal cohort of Russian boys. METHODS: A total of 489 Russian boys were enrolled in 2003-2005, at 8 to 9 years of age, and were monitored annually through May 2008. Cox proportional-hazards models were used to evaluate the association of BLLs at enrollment with time to pubertal onset during follow-up monitoring. RESULTS: A total of 481 boys had BLLs, with a median of 3 mu g/dL and 28% with values of >= 5 mu g/dL. The proportion of pubertal boys increased with age, from 12% at age 8 to 83% at age 12 for testicular volume of >3 mL, from 22% to 90% for genitalia stage 2 or higher, and from 4% to 40% for pubic hair stage 2 or higher. After adjustment for potential confounders including BMI and height, boys with high BLLs (>= 5 mu g/dL) had 24% to 31% reduced risk of pubertal onset, on the basis of testicular volume of >3 mL (hazard ratio [HR]: 0.73 [95% confidence interval [CI]: 0.55-0.97]; P = .03), genitalia staging (HR: 0.76 [95% CI: 0.59-0.98]; P = .04), and pubic hair staging (HR: 0.69 [95% CI: 0.44-1.07]; P = .10), compared with those with lower BLLs. Pubertal onset occurred 6 to 8 months later, on average, for boys with high BLLs, compared with those with BLLs of <5 mu g/dL. CONCLUSION: Higher BLLs were associated with later pubertal onset in this prospective study of peripubertal Russian boys. Pediatrics 2010; 125: e1088-e1096
- Добавил в систему: Сергеев Олег Владимирович