Impact of constitutional copy number variants on biological pathway evolutionстатья
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Дата последнего поиска статьи во внешних источниках: 17 декабря 2015 г.
Аннотация:Inherited Copy Number Variants (CNVs) can modulate the expression levels of individual genes. However, little is known about how CNVs alter biological pathways and how this varies across different populations. To trace potential evolutionary changes of well-described biological pathways, we jointly queried the genomes and the transcriptomes of a collection of individuals with Caucasian, Asian or Yoruban descent combining high-resolution array and sequencing data.