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Two-dimensional Al hydroxide interaction with cancerous cell membrane building units: Complexed free energy and orientation analysisстатья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 1 октября 2025 г.
- Авторы: Tsukanov A.A., Psakhie S.G.
- Сборник: AIP Conference Proceedings
- Том: 1882
- Год издания: 2017
- Издательство: AIP Publishing LLC
- Местоположение издательства: United States
- Первая страница: 020076
- Последняя страница: 020076
- Номер статьи: 020076
- DOI: 10.1063/1.5001655
- Аннотация: The application of hierarchical nanoparticles based on metal hydroxides in biomedicine, including anticancer therapy and medical imaging, is a rapidly developing field. Low-dimensional aluminum oxyhydroxide nanomaterials (AlOOH-NM) are quite promising base to develop hybrid theranostic nano-agents with core-shell architecture, which is determined by AlOOH-NMs physicochemical properties such as: large specific surface area, pH-dependent charge, amphoteric behavior, high surface density of polar groups capable to form non-covalent bonds, low or null cytotoxicity and biocompatibility. Characterization of the system behavior within interface between NM and plasmatic membrane is crucial for the understanding of nano-agent—cell interaction. In the present work the complex in silico study including the free energy estimation and orientation analysis of phosphatidylcholine (POPC) and phosphatidylethanolamine (POPE) lipids interacting with AlOOH nanosheet was conducted to understand the effect of such nanomaterial on cancerous cell plasmatic membrane.Topics: Free energy, Nanoparticle, Chemical compounds, Chemical properties, Lipids, Medical diagnosis, Medical imaging, Cytotoxicity, Biomaterials, Cell membraneshttps://doi.org/10.1063/1.5001655
- Добавил в систему: Цуканов Алексей Алексеевич