Polymorphism of dopamine related genes in the light of psychodermatology: Association with psoriasisстатья Тезисы

Статья опубликована в высокорейтинговом журнале

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Дата последнего поиска статьи во внешних источниках: 26 февраля 2018 г.

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[1] Polymorphism of dopamine related genes in the light of psychodermatology: Association with psoriasis / V. Sobolev, E. Klimov, A. Tretiakov et al. // Journal of Investigative Dermatology. — 2017. — Vol. 137, no. 10. — P. S230–S230. Psoriasis is a multigene and multifactorial skin disease with heterogeneous genetic inheritance. Mental disorders participate in the development of psoriasis as predisposing factors; a correlation of dermatological diseases with pathological anxiety and stress was shown. Meanwhile, there are no studies describing molecular mechanisms of the linkages between psycho-emotional disorders and skin diseases. The aim of this study is to find the associations between SNV in genes COMT (rs4680), DBH (rs141116007), CCKAR (rs1800857) and CCKBR (rs1805002), and psoriasis. The products of genes researched in this work are responsible for the release of (CCKAR), regulate the reuptake (CCKBR) of dopamine, and are responsible for its degradation (COMT and DBH). In our study The 2 test revealed an association with psoriasis only for the COMT gene, which encodes catechol-O-methyltransferase. Results of polygenic analysis also showed a significant influence of gene polymorphism COMT (rs4680) in the development of psoriasis. The carrying of both alleles in combinations with other alleles forms the strongly associated patterns. Besides, the G allele, both alone and in combination with other genes and / or A allele, forms markers of strong predisposition to the disease. The AA genotype in the meantime is protective. This indicates the dominant manifestation of the G allele in the case of psoriasis. The association of GA genotype of COMT gene with psoriasis found in our study has no direct explanation of its functional activities. The most interesting hypothesis, which could explain the effect of the GA heterozygote of the COMT gene on the pathogenesis of psoriasis, from our point of view, is the possibility of changing the activity of the heterodimer. Thus, it was shown that COMT enzyme can exist in three forms: a monomer, a membrane-bound monomer and a dimer. The structure of proteins COMT 158Val and COMT 158Met is different, which results in different affinity to substrates and different stability of the enzyme. Perhaps the heterodimer has an affinity for other substrates. Thus, patients with psoriasis have an increased excretion of adrenaline in stressful situations. Perhaps affinity for adrenaline becomes lower, which contributes to its accumulation in patients. [ DOI ]

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