[1] | Urokinase increases the content and activity of matrix metalloproteinases 2 and 9 during in vivo constrictive arterial remodeling / M. A. Solomatina, O. S. Plekhanova, M. Y. Men’shikova et al. // Bulletin of Experimental Biology and Medicine. — 2005. — Vol. 139, no. 3. — P. 283–286. Perivascular application of urokinase to ballooned artery stimulating the formation of neointima and constrictive arterial remodeling increased the content and activity of matrix metalloproteinases 2 and 9 in vivo. Application of recombinant tissue plasminogen produced no such changes. It was demonstrated that urokinase stimulates expression of matrix metalloproteinases in vivo. |