Sorption Concentration of Phenylcarboxylic Acids(Biomarkers of Sepsis) from Standard Test Solutionson HyperCrossLinked Polystyreneстатья
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Дата последнего поиска статьи во внешних источниках: 12 января 2015 г.
Аннотация:Sorption conditions (on hypercrosslinked polystyrene) have been developed for six phenylcar
boxylic acids (PCA), which are biomarkers of sepsis, from aqueous standard test solutions and conditions of
elution of these acids for subsequent derivatization and analysis by gas chromatography–mass spectrometry
(GC–MS). The conditions facilitate detection of PCA in solution at the level (and below) of content of these
compounds in blood serum of normal patients. Group extraction of different in polarity required acids from
aqueous solutions has been performed selectively with regard to cholesterol adopted as peculiar marker of high
boiling interfering compounds. Application of the developed experimental procedure will make it possible to
increase significantly the rate of express analysis for diagnostics of sepsis at early stages of development.