Cell response kinetics: the phenomenon of supercooperativity in aggregation of human plateletsстатья

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Дата последнего поиска статьи во внешних источниках: 5 декабря 2014 г.

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[1] Cell response kinetics: the phenomenon of supercooperativity in aggregation of human platelets / P. V. Vrzheshch, A. V. Tatarintsev, D. E. Ershov, S. D. Varfolomeev // Thrombosis Research. — 1992. — Vol. 66, no. 5. — P. 537–547. Concentration - response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: hADP = hL-EPINEPHRINE = hPAF = hPGH2 = hU46619 < hPMA < hA23187 < hMERTHIOLATE = hARACHIDONATE. The results were interpreted in terms of a model assuming varying degrees of cooperativity for each step of signal transduction involved in platelet aggregation. Super-high values of h (>30) obtained with arachidonate and merthiolate, as well as in the case of inhibition of an arachidonate-induced response by indomethacin and PTA 2, suggested that at least one region of signal transduction pathway leading to aggregation exhibited supercooperative properties. [ DOI ]

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