Preparation and characterization of lipid microcapsules coated with SiO2@Al2O3 core-shell nanoparticles as carries for lipophilic drug deliveryстатья Исследовательская статья

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 ноября 2017 г.

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[1] Koroleva M., Gorbachevski O., Yurtov E. Preparation and characterization of lipid microcapsules coated with sio2@al2o3 core-shell nanoparticles as carries for lipophilic drug delivery // Materials Chemistry and Physics. — 2017. — Vol. 202. — P. 1–6. Solid lipid microparticles coated with silica nanoparticles and loaded with lipophilic drugs: curcumin, hydrocortisone, nimesulide or a-tocopherol were investigated. Complex stabilization of paraffin microparticles was achieved through the formation of steric multicomponent adsorption layer of surfactant Eumulgin O10, polyvinyl alcohol (PVA), and SiO2@Al2O3 core-shell nanoparticles, which provided protective action and steric hindrance to coalescence before paraffin solidification and to aggregation after paraffin solidification. Lipid particles with sizes in the range from 365 to 700 nm were produced using the combined effect of three types of stabilizer. High encapsulation efficiency was demonstrated; almost all the amounts of drugs were encapsulated in paraffin microcapsules. The results indicate that paraffin microparticles coated with silica nanoparticles are promising for application as delivery systems for lipophilic compounds. [ DOI ]

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