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On statistical relationship between ADRA2A expression and the risk of breast cancer relapseстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 мая 2015 г.
- Авторы: Shkurnikov M.Y., Galatenko V.V., Lebedev A.E., Podol'skii V.E., Tonevitskii E.A., Mal'tseva D.V.
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 157
- Номер: 4
- Год издания: 2014
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 454
- Последняя страница: 458
- DOI: 10.1007/s10517-014-2589-7
- Аннотация: The search for novel parameters to predict the risk of relapse in breast cancer was conducted. Significant correlation between the risk of relapse and α-2A adrenergic receptor (ADRA2A) expression was revealed using public microarray datasets. This relationship was confirmed by validation on independent microarray dataset. It was found that when assessing the risk of BC relapse, the accuracy of prediction based solely on the expression of ADRA2A gene is close to that made using OncotypeDX and MammaPrint test systems. In this case, addition of only one or two supplemental prognostic markers (for instance, expression of SQLE gene or SQLE and DSCC1genes) to ADRA2A ensures the accuracy of prediction not inferior to reliability of these test systems.
- Добавил в систему: Галатенко Владимир Владимирович