Аннотация:For a long time, it was widely accepted that the biological effects of ionizing radiation such as cell
death, DNA damage, and mutagenesis result from the direct ionization of cell structures, particularly
DNA, or from indirect damage through reactive oxygen species produced by the radiolysis of water.
This “targeted effect” (TE) model has been questioned by numerous observations, in which cells,
that were not directly irradiated, exhibited responses similar to those of the directly irradiated cells.
Therefore, it is nowadays accepted that the detrimental effects of ionizing radiation are not restricted
only to the irradiated cells, but also to non-irradiated adjacent or distant cells