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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Plaur and Plat genes are early upregulated in response to environmental novelty in mouse brainстатья
- Авторы: Klimovich Polina, Ivashkina Olga I., Toropova Ksenia, Rogozhnikova Olga, Shchipova Anna, Anokhin Konstantin, Popov Vladimir, Rubina Kseniya, Tkachuk Vsevolod, Semina Ekaterina
- Журнал: Neuroscience and Behavioral Physiology
- Том: 55
- Год издания: 2025
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 271
- Последняя страница: 282
- DOI: 10.1007/s11055-025-01752-9
- Аннотация: Understanding the molecular underpinnings of learning and memory processes remains a focal point in neuroscience. Exposure to novel environments promotes learning and memory formation. This study investigated the role of two activity-regulated immediate early genes, Plaur (encodes urokinase receptor, uPAR) and Plat (encodes tissue plasminogen activator, tPA), in response to environmental novelty in the mouse brain. As integral components of the plasminogen activator system, these genes contribute to synaptic plasticity, neuronal migration, and brain function. Using the open field as a model of novelty, we demonstrated a rapid, within 1 h after exposure, induction of Plaur and Plat expression in the posterior cortex and hippocampus. Immunofluorescence staining corroborates the upregulation of tPA protein in hippocampus 24 h following open field exposure. Additionally, a brief one-hour exposure to an enriched environment triggers an early induction of Plaur expression in the anterior cortex, while prolonged exposure for 24 h results in a transient downregulation of Plat in the posterior cortex. These findings highlight the dynamic regulation of immediate early genes in response to environmental novelty, providing insights into the molecular mechanisms underlying cognitive processes and the involvement of the plasminogen activator system in these processes. Further analysis of the expression of plasminogen activator genes under conditions of novelty exposure and learning will allow us to identify new molecular targets that describe the mechanisms of learning and memory encoding in the brain.
- Добавил в систему: Климович Полина Сергеевна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Plau_and_Plat_ERG.pdf | 3,5 МБ | 19 мая 2025 [KlimovichPolina] | |
| 2. | Полный текст | Klimovich_et_al._Neurosci_2025.pdf | 3,3 МБ | 21 марта 2025 [e-semina@yandex.ru] |