A Joint Analysis of RNA-DNA and DNA-DNA Interactomes Reveals Their Strong Association

Авторы: Zvezdin Dmitry S., Tyukaev Artyom A., Zharikova Anastasia A., Mironov Andrey A.
Журнал: International Journal of Molecular Sciences
Том: 26
Номер: 3
Год издания: 2025
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 1137
Последняя страница: 1137
DOI: 10.3390/ijms26031137
Аннотация: At the moment, many non-coding RNAs that perform a variety of functions in the regulation of chromatin processes are known. An increasing number of protocols allow researchers to study RNA-DNA interactions and shed light on new aspects of the RNA–chromatin interactome. The Hi-C protocol, which enables the study of chromatin’s three-dimensional organization, has already led to numerous discoveries in the field of genome 3D organization. We conducted a comprehensive joint analysis of the RNA-DNA interactome and chromatin structure across different human and mouse cell lines. We show that these two phenomena are closely related in many respects, with the nature of this relationship being both tissue specific and conserved across humans and mice.
Добавил в систему: Миронов Андрей Александрович

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