Hibernation enhances contractile responses of basilar artery in ground squirrels: The role of Rho-kinase and NO

Gaynullina, D.K.; Shvetsova, A.A.; Borzykh, A.A.; Kiryukhina, O.O.; Sirotina, N.S.; Abramochkin, D.V.; Tarasova, O.S.

Авторы: Gaynullina Dina K., Shvetsova Anastasia A., Borzykh Anna A., Kiryukhina Oxana O., Sirotina Natalia S., Abramochkin Denis V., Tarasova Olga S.
Журнал: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Том: 301
Год издания: 2025
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Номер статьи: 111796
DOI: 10.1016/j.cbpa.2024.111796
Аннотация: Hibernation is accompanied by dramatic decrease of blood flow in many organs due to the increase of their vascular resistances. We compared the responses of mesenteric, renal, and cerebral proximal resistance arteries in summer active (SA) and winter hibernating (WH) ground squirrels and studied the signaling pathways of Rho-kinaseand NO. Wire myography and Western blotting were used to assess the arterial responses and proteinabundances. Basal tone and contractile responses did not differ between SA and WH squirrels in mesenteric and renal arteries, but were greatly increased in basilar arteries of WH compared to SA. Rho-kinase inhibitor abolished the differences in basilar artery basal tone and contractile responses between WH and SA squirrels, whilethe content of Rho-kinase II protein in the cerebral arteries did not differ between the groups. NO-synthase inhibitor increased basal tone level and basilar artery contractile responses only in SA but not in WH animals, so that the intergroup differences disappeared. The responses of basilar artery to the NO-donor and eNOS proteincontent did not differ between the two groups, while nNOS protein content was reduced in WH compared to SA.Therefore, the increase of basilar artery basal tone and contractile responses in hibernating animals is due to the increase of procontractile influence of Rho-kinase and the decrease of anticontractile influence of NO. Localizationof high resistance in the hibernating brain at the level of proximal resistance arteries may be important for rapid restoration of cerebral blood flow upon arousal from hibernation.
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