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Hybrid plasmonic nanodiamonds for thermometry and local photothermal therapy of melanoma: a comparative study. Nanophotonicsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Gerasimova EN, Fatkhutdinova LI, Vazhenin Uvarov EI, Vysotina E., Mikhailova L., Lazareva PA, Kostyushev D., Abakumov M., Parodi A., Yaroshenko Zuev DA, Zyuzin MV
- Журнал: NANOPHOTONICS
- Том: 13
- Номер: 22
- Год издания: 2024
- Издательство: Walter de Gruyter
- Местоположение издательства: Berlin, Germany
- Первая страница: 4111
- Последняя страница: 4125
- DOI: 10.1515/nanoph-2024-0285
- Аннотация: Hyperthermia plays a significant role in cancer treatment by inducing cell damage through temperature elevation, often used alongside other treatment modalities. During hyperthermia therapy, temperature control is crucial. Here, we report on a simple synthesis route of hybrid plasmonic nanodiamonds either completely wrapped with an Au shell (NV@Au) or densely covered with Au NPs (NV@SiO 2 @Au). Such integration of nanodiamonds with Au NPs is advantageous both for heating and precise thermometry at nanoscale. After structural and optical investigations, heating abilities of the obtained plasmonic nanodiamonds were thoroughly inspected on glass, in association with living cells, and in tissue slices ex vivo, revealing their effective heat generation under excitation with light using a single excitation source. The developed hybrid plasmonic nanodiamonds were finally applied for local photothermal therapy of melanoma in vivo, demonstrating their efficacy in eradicating cancer cells and monitoring temperature during the process.
- Добавил в систему: Костюшев Дмитрий Сергеевич