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Gausemycin Antibiotic Family Acts via Ca2+-Dependent Membrane Targetingстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 декабря 2024 г.
- Авторы: Kravchenko Tatyana V., Paramonov Alexander S., Kudzhaev Arsen M., Efimova Svetlana S., Khorev Alexey S., Kudryakova Gulnara Kh, Ivanov Igor A., Chistov Alexey A., Baranova Anna A., Krasilnikov Maxim S., Lapchinskaya Olda A., Tyurin Anton P., Ostroumova Olga S., Smirnov Ivan V., Terekhov Stanislav S., Dontsova Olga A., Shenkarev Zakhar O., Alferova Vera A., Korshun Vladimir A.
- Журнал: Journal of Natural Products
- Том: 87
- Номер: 4
- Год издания: 2024
- Издательство: American Chemical Society
- Местоположение издательства: United States
- Первая страница: 664
- Последняя страница: 674
- DOI: 10.1021/acs.jnatprod.3c00612
- Аннотация: We report the molecular mechanism of action of gausemycins and the isolation of new members of the family, gausemycins C (), D (), E (), and F (), the minor components of the mixture. To elucidate the mechanism of action of gausemycins, we investigated the antimicrobial activity of the most active compounds, gausemycins A and B, in the presence of Ca, other metal ions, and phosphate. Gausemycins require a significantly higher Ca concentration for maximum activity than daptomycin but lower than that required for malacidine and cadasides. Species-specific antimicrobial activity was found upon testing against a wide panel of Gram-positive bacteria. Membranoactivity of gausemycins was demonstrated upon their interactions with model lipid bilayers and micelles. The pore-forming ability was found to be dramatically dependent on the Ca concentration and the membrane lipid composition. An NMR study of gausemycin B in zwitterionic and anionic micelles suggested the putative structure of the gausemycin/membrane complex and revealed the binding of Ca by the macrocyclic domain of the antibiotic.
- Добавил в систему: Бачева Анна Владимировна