Reconstruction of the Reaction of Andalusicin Lantibiotic Modification by Lanthionine Synthetase AncKC in a Heterologous Escherichia coli System

Авторы: Mirzoeva N.Z., Pipiya S.O., Mokrushina Yu A., Serebryakova M.V., Grigorieva A.A., Dubiley S.A., Terekhov S.S., Smirnov I.V.
Журнал: Acta Naturae (русскоязычная версия)
Том: 16
Номер: 3
Год издания: 2024
Издательство: Парк-медиа
Местоположение издательства: М.
Первая страница: 46
Последняя страница: 50
DOI: 10.32607/actanaturae.27347
Аннотация: The increasing resistance of microorganisms to antibiotics makes it a necessity that we search fornew antimicrobial agents. Due to their genetically encoded nature, peptides are promising candidates for newantimicrobial drugs. Lantipeptide andalusicin exhibits significant antimicrobial activity against Gram-positivebacteria, making it a promising scaffold for the development of DNA-encoded libraries of lantibiotics. In thisstudy, the modification reaction of andalusicin by class III lanthionine synthetase AncKC was reconstructedin a heterologous Escherichia coli system. The results obtained open possibilities for creating novel peptide-based antimicrobial agents.KEYWORS lanthipeptides, posttranslational modifications, antimicrobial peptides.
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