Regulation of Vascular Smooth Muscle Cell Contraction during Early Postnatal Ontogenesis

Авторы: Gaynullina D.K., Tarasova O.S., Shvetsova A.A.
Журнал: Moscow University Biological Sciences Bulletin
Том: 79
Номер: Suppl 1
Год издания: 2024
Издательство: Allerton Press
Местоположение издательства: New York, N.Y., United States
Первая страница: S49
Последняя страница: S58
DOI: 10.3103/S0096392524600777
Аннотация: Growth of the body in early postnatal ontogenesis is associated with changes in the functioning ofmany systems, including the cardiovascular system. The circulatory system of newborns is characterized bynumerous structural and functional features, which are manifested at the systemic level in significantly lower arterial pressure. This review considers the differences in the mechanisms regulating vascular smooth muscle cell contraction in early postnatal ontogenesis and in adulthood, including age-related changes in the functioning of ion channels, the activity of which affects the level of membrane potential and intracellular concentration of calcium ions as well as changes in the calcium sensitivity of the contractile apparatus. The final section of the review discusses the relationship between the mechanisms regulating contraction and differentiationof vascular smooth muscle cells during their maturation.
Добавил в систему: Тарасова Ольга Сергеевна

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